The kinetics of glutathione in the gastrointestinal tract of weaned piglets supplemented with different doses of dietary reduced glutathione

This study aimed to investigate the kinetics of dietary GSH in gastrointestinal tract and effect on intestinal redox status weaned piglets. Forty-eight piglets with an average age 26 days body weight 7.7 kg were used this study. The divided into three treatment groups including control group a basal diet (CON) two supplemented 0.1% (LGSH) 1.0% (HGSH), respectively. did not contain any GSH. experiment lasted for 14 days, eight animals sampled from each d5 14. parts 0–5%, 5–75%, 75–100% length small intestine assigned SI1, SI2, SI3. results showed that almost completely disappeared digesta at SI2. However, no difference level mucosa, liver, blood erythrocytes was found. cysteine (CYS) SI1 significantly higher HGSH than CON LGSH d14, similar findings observed cystine (CYSS) SI3 d5. CYSS also stomach while CYS or detected animals, indicating breakdown already occurred stomach. Irrespective treatment, d14 increased when moving more distally tract. Furthermore, mucosal compared Glutathione disulfide (GSSG) recovered diets group, which could demonstrate auto-oxidation It is, therefore, concluded supplementation increase piglets, potentially relate digestive tract, where seemed be prone GSSG.